Thermo Fisher Scientific IL-17A Polyclonal Antibody
IL-17A 단백질을 인식하는 토끼 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot 및 IHC(파라핀) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 염증 관련 연구 및 세포 신호 연구에 유용한 연구용 시약입니다.
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Thermo Fisher Scientific IL-17A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human IL17A (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913141 |
Product Specific Information
Store as a concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in conditions such as rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer consisting of 136 amino acids, a member of the IL-17 family (IL-17A–F), signaling through IL-17 receptor (IL-17R/CDw217).
It enhances expression of ICAM-1 in human fibroblasts and stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
In the presence of IL-17A, fibroblasts can support CD34+ hematopoietic progenitor proliferation and neutrophil maturation.
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, showing cross-species receptor recognition.
IL-17A regulates NF-κB and MAPK activities, stimulates IL-6 and COX-2 expression, and enhances nitric oxide (NO) production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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