Thermo Fisher Scientific IL-17A Polyclonal Antibody

Thermo Fisher Scientific IL-17A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store as a concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in conditions such as rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer consisting of 136 amino acids, a member of the IL-17 family (IL-17A–F), signaling through IL-17 receptor (IL-17R/CDw217).
It enhances expression of ICAM-1 in human fibroblasts and stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
In the presence of IL-17A, fibroblasts can support CD34+ hematopoietic progenitor proliferation and neutrophil maturation.
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, showing cross-species receptor recognition.
IL-17A regulates NF-κB and MAPK activities, stimulates IL-6 and COX-2 expression, and enhances nitric oxide (NO) production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.