Thermo Fisher Scientific beta Amyloid Polyclonal Antibody

Applications and Tested Dilution

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Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process.
The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE), which is synthesized as a propeptide and activated by the prohormone convertase, furin. The mature BACE form cleaves beta APP, producing a secreted segment and a membrane-bound remnant.
This remnant is further processed by gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, and nicastrin, which binds to the carboxyl-terminus of beta APP and modulates amyloid beta peptide production.
Abeta is an extracellular filamentous protein component of amyloid cores and neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.

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