Thermo Fisher Scientific AFAP1L2 Polyclonal Antibody
AFAP1L2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ELISA에 적합. Human, Mouse, Rat 반응성. KLH 결합 합성 펩타이드 면역원 사용. 고순도의 Protein A 정제 항체로 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human AFAP1L2 (amino acids 751–818) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
AFAP1L2 (also known as XB130) is structurally similar to actin-filament-associated protein (AFAP), containing multiple SH2- and SH3-binding motifs, pleckstrin homology domains, a coiled-coil region, and several phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase.
Suppression of AFAP1L2 via siRNA reduces Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3β, and alters cell cycles in human lung epithelial cells, suggesting its role as an adaptor in Src signal transduction and cellular functions.
AFAP1L2 is highly expressed in thyroid tissue and acts as a substrate for RET/PTC kinase, which is implicated in papillary thyroid cancer. Down-regulation of AFAP1L2 reduces Akt activity, inhibiting cell-cycle progression and cancer cell survival, indicating its potential as a therapeutic target in thyroid cancer.
At least four isoforms of AFAP1L2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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