Thermo Fisher Scientific PATZ1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
LLDSMFGSPG GLREAGILPC GLCGKVFTDA NRLRQHEAQH GVTSLQLGYI DLPPPRLGEN GLPISEDPDG PRKRSRTRKQ VACEI

Highest antigen sequence identity to orthologs:

• Mouse: 100%
• Rat: 100%

Target Information

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its POZ domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression.

In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12)). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene, creating a chimeric sequence containing the transactivation domain of EWS fused to the zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.