Thermo Fisher Scientific N4BP2L2 Polyclonal Antibody
Human N4BP2L2 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. 단백질 발현 및 전사 조절 연구에 적합. 연구용 한정.
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human N4BP2L2. Recombinant protein control fragment: RP-106928 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2856893 |
Product Specific Information
Immunogen sequence:
GPREEVTSEP RCKKLKSTTE SYVFHNHSNA DFHRIQEKTG NDWVPVTIID VRGHSYLQEN KIKTTDLHRP LHDEMPGNRP DVIESIDSQV LQEAR
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation.
N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, likely by ATM or ATR. It is primarily expressed in bone marrow and is significantly down-regulated after exposure to arsenic compounds, preceding neutropenia.
PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase (ELA2) cause cyclic haematopoiesis, characterized by decreased circulating neutrophils and increased susceptibility to opportunistic infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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