Thermo Fisher Scientific MRCK gamma Polyclonal Antibody
MRCK gamma 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(Paraffin)에 최적화됨. Human 및 Mouse 시료에 반응하며, Affinity chromatography로 정제됨. 세포 골격 재구성과 관련된 CDC42BPG 단백질 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDC42BPG (Accession Q6DT37), corresponding to amino acid residues L1393–F1443. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850266 |
Product Specific Information
Antibody detects endogenous levels of total MRCKG.
Target Information
CDC42 BPG serine/threonine kinase is encoded by the CDC42BPG gene. It acts as a downstream effector of CDC42 in cytoskeletal reorganization and contributes to the actomyosin contractility required for cell invasion through the regulation of MYPT1 and MLC2 phosphorylation.
It belongs to the AGC protein kinase family, DMPK subfamily, and contains:
- N-terminal kinase domain
- Two coiled-coil domains (one containing a kinase inhibitory motif, KIM)
- Variable region
- Cysteine-rich domain
- Pleckstrin homology (PH) domain
- Citron homology (CNH) domain
- C-terminal CDC42/RAC interactive binding (CRIB) domain
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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