Thermo Fisher Scientific LRP5 Polyclonal Antibody
Thermo Fisher Scientific의 LRP5 Polyclonal Antibody는 인간 LRP5 단백질을 인식하는 염소 유래 다클론 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 고순도의 액상 형태로 제공됩니다. 마우스와 랫트에서도 반응이 예측됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (ERVEKTTGDKRT) corresponding to the internal amino acids of LRP5 (aa 1178–1190) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10979335 |
Product Specific Information
- This antibody is predicted to react with mouse and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
LDL-related proteins, LRP5 and LRP6, are members of the LDL receptor superfamily involved in the canonical Wnt signaling pathway.
LRP6 binds to Wnt1 and enhances Wnt-induced developmental processes in Xenopus embryos.
Mice lacking LRP6 exhibit developmental defects similar to those caused by deficiencies in Wnt proteins.
Wnt proteins induce the binding of LRP5 to Axin, leading to Axin degradation and β-catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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