Thermo Fisher Scientific PXR Polyclonal Antibody
PXR 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, Flow Cytometry, ELISA에 적합합니다. Human, Mouse, Pig, Rat에 반응하며, Protein A로 정제된 1 mg/mL 액상 형태입니다. -20°C 보관, 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Flow Cytometry (Flow) | 1:50 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PXR, amino acids 51–150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene product belongs to the nuclear receptor superfamily, whose members are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein regulates transcription of the cytochrome P450 gene CYP3A4, binding to its promoter response element as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by various compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms have been described, some utilizing non-AUG initiation codons. Additional variants may exist but are not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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