Thermo Fisher Scientific IL-12 p35 Polyclonal Antibody
Goat polyclonal antibody against human IL-12 p35 subunit. Validated for IHC (paraffin) and peptide ELISA. Provides high specificity and sensitivity for cytokine signaling studies. Supplied as liquid form, unconjugated, with 0.5 mg/mL concentration for ...
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- PA5142428
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- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence PCTSEEIDHEDITK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933076 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Interleukin 12A (IL-12A) is a signaling cytokine belonging to the Interleukin-6 superfamily. The IL-12A alpha chain precursor is a 35-kD subunit of the disulfide-linked heterodimer IL-12, exhibiting diverse biological activities.
IL-12A acts as a growth factor for activated T and NK cells, enhancing the lytic activity of NK/lymphokine-activated killer cells. It stimulates IFN-gamma production by resting PBMCs and supports T-cell-independent induction of IFN-gamma.
Additionally, IL-12A aids in differentiation of Th1 and Th2 cells and positively regulates tyrosine phosphorylation of Stat4 protein. The innate immune signaling of IL-12A involves nitric oxide synthase 2A.
Together with EBI3, IL-12A forms the heterodimeric cytokine IL-35, produced by T reg cells and essential for maximal suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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