Thermo Fisher Scientific CTDSP1 Polyclonal Antibody
Goat polyclonal antibody targeting CTDSP1 for human samples. Validated for WB and IHC-P with high specificity. Recognizes both reported isoforms and suitable for research applications. Supplied as liquid, unconjugated form with 0.5 mg/mL concentration.
- 카탈로그번호
- PA5142266
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 5 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-RGKGDQKSAASQK (aa 20–32) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932919 |
Product Specific Information
This antibody is expected to recognize both reported isoforms (NP_067021.1 and NP_872580.1).
Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibits activated transcription from several promoter-reporter gene constructs, while a mutant lacking phosphatase activity enhances transcription.
Neuronal gene transcription is repressed in nonneuronal cells by the REST/NRSF complex, which recruits SCPs to neuronal genes containing RE1 elements, leading to silencing. Phosphatase-inactive SCP forms interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Similarly, RNA interference targeting the single Drosophila SCP unmasks neuronal gene expression in S2 cells. SCP activity is thus an evolutionarily conserved transcriptional regulator that globally silences neuronal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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