Thermo Fisher Scientific GJA1 Monoclonal Antibody (3E5)
Thermo Fisher Scientific의 GJA1 Monoclonal Antibody (3E5)는 인간 Connexin 43 단백질을 인식하는 Mouse IgG1 항체입니다. Western blot과 ELISA에 적합하며, 액상 형태로 제공됩니다. PBS buffer에 보존되며 -20°C에서 보관 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E5 |
| Immunogen | GJA1 (AAH26329, 261–361 a.a.) partial recombinant protein with GST tag (MW of GST tag = 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GSQKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNSKKLAAG HELQPLAIVD *
Target Information
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins form hexamers that create hemichannels, enabling intercellular communication. These channels assemble into gap junctions, crucial for development and cell growth regulation.
Phosphorylation of Cx43, particularly at Ser368 by PKC, modulates gap junction communication. Src kinase can also interact with and phosphorylate Cx43.
Connexin 43 is the major gap junction protein in the heart, essential for synchronized contraction and embryonic development. It is regulated by multiple kinases affecting myocardial coupling.
A related pseudogene, GJA1P, is mapped to chromosome 5. Mutations in GFAP are associated with X-linked Charcot-Marie-Tooth disease, oculodentodigital dysplasia, and heart malformations.
Alternatively spliced transcript variants of GFAP have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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