Thermo Fisher Scientific Podoplanin Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa. It is expressed in various tumors and normal cells, particularly lymphatic epithelial cells and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells.

As a regulator of lymphatic endothelium, podoplanin likely contributes to maintaining the unique shape of podocytes. It serves as a ligand for CLEC-2, and its expression correlates with tumor invasiveness and metastatic potential. Podoplanin is directly involved in cell migration, metastasis formation, and tumor cell invasion.

Its expression is induced through Src activation of Cas, and recent findings suggest its presence on Th17 cells. Studies indicate a small but distinct population of CD4+ cells from human PBMC expressing podoplanin. Dysfunction of this protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to its physiological role.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.