Thermo Fisher Scientific RUNX1T1 Monoclonal Antibody (OTI1H1), TrueMAB
RUNX1T1 단백질을 인식하는 Mouse monoclonal 항체로 Western blot과 Immunocytochemistry에 적합. Affinity chromatography로 정제된 액상 항체이며, 1 mg/mL 농도. PBS, BSA, glycerol buffer에 보존되며 -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H1 |
| Immunogen | Full length human recombinant protein of RUNX1T1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein.
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities.
This translocation produces a chimeric gene composed of the 5′ region of the RUNX1 gene fused to the 3′ region of RUNX1T1.
The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Several transcript variants encoding multiple isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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