Thermo Fisher Scientific NALCN Polyclonal Antibody
Human NALCN 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공. 연구용으로만 사용 가능하며 장기 보관 시 -20°C에서 보관 권장.
- 카탈로그번호
- PA556887
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NALCN. Recombinant protein control fragment (Product #RP-95697). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644447 |
Product Specific Information
- Immunogen sequence:
TYHCVVNDTK PGNVTWNSLA IPDTHCSPEL EEGYQCPPGF KCMDLEDLGL SRQELGYSGF NE - Highest antigen sequence identity:
Mouse - 100%, Rat - 100%
Target Information
Nalcn is a voltage-independent, cation-nonselective channel permeable to sodium, potassium, and calcium ions. It regulates resting membrane potential and neuronal excitability. Neuropeptides such as neurotensin and substance P stimulate NALCN activation via SRC family kinases. Nalcn is involved in respiratory rhythm, osmoregulation, and intestinal pacemaking activity. It also plays a role in maintaining spontaneous firing and modulation of substantia nigra pars reticulata neurons.
Diseases associated with NALCN include congenital contractures, developmental delay, hypotonia, and infantile psychomotor retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-56887_NALCN_Q8IZF0-1_Rabbit.svg, PA5-56887_NALCN_Q8IZF0-1_Rabbit_PDP.jpeg)
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