Thermo Fisher Scientific CRTH2 Polyclonal Antibody
CRTH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC 및 ICC/IF에 사용 가능. 인간 및 비인간 영장류 반응성. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 알레르기 반응 및 Th2 세포 연구용으로 적합.
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- PA533721
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Thermo Fisher Scientific CRTH2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 16–32 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 3rd extracellular domain of human GPR44 / CRTH2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551094 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey (100%)
Gibbon (95%)
Panda, Dog (90%)
Elephant, Bovine, Horse (85%)
Target Information
CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells that acts as a receptor for prostaglandin D2 (PGD2) and prostaglandin D receptor. It mediates chemotaxis of Th2 cells and eosinophils to PGD2, playing a crucial role in allergic responses.
CRTH2 knockout mice showed enhanced eosinophil recruitment and increased IL-5 and IL-3 production, suggesting CRTH2 restricts eosinophilia and allergic responses in vivo. It is a member of the G protein-coupled leukocyte chemoattractant receptor family, selectively expressed in Th2 lineage cells.
CRTH2 expression has been reported in the central nervous system, peripheral tissues, and blood cells, particularly in activated Th2 cells. Two transcripts have been identified:
- 3.5 kb transcript: thalamus, frontal cortex, pons, hippocampus
- 3.4 kb transcript: fetal liver, leukocytes, thymus
CRTH2 is expressed in activated Th2 cells, including allergen-responsive Th2 cells, indicating its pivotal role in Th2-type immune reactions. At least two isoforms of CRTH2 are known. SNPs in the 3′ UTR of the CRTH2 gene have been associated with asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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