Thermo Fisher Scientific CDKN1A Monoclonal Antibody (OTI4B11), TrueMAB
CDKN1A(p21) 단백질을 인식하는 Mouse monoclonal antibody(OTI4B11)로, Western blot 및 IHC(P) 검증 완료. 인간 시료 반응성, 1 mg/mL 농도의 액상 항체. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보존. 종양 억제 단백질 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2–164 of human CDKN1A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
P21 plays a key role in the cellular response to genotoxic stress and acts as a major transcriptional target of p53.
In the nucleus, p21 binds and inhibits CDK1 and CDK2, blocking cell cycle progression from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair.
In the cytoplasm, p21 exhibits anti-apoptotic functions by binding and inhibiting caspase-3, ASK1, and JNK.
P21 thus has dual roles in carcinogenesis—acting both as a tumor suppressor and as an oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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