Thermo Fisher Scientific ING4 Polyclonal Antibody
Human ING4 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공. 종양 억제 단백질 연구 및 NF-κB 경로 관련 연구에 적합.
- 카탈로그번호
- PA5111xxx (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ING4 Polyclonal Antibody
Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ING4. Recombinant protein control fragment: Product #RP-95605 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2856441 |
Product Specific Information
Immunogen sequence:
EKQIESSDYD SSSSKGKKKG RTQKEKKAAR ARSKGKNSDE EAPKTAQKKL KLVRTSPEYG MPSVTFGSVH
Target Information
The ING4 gene belongs to the Inhibitor of Growth (ING) family of tumor suppressors. All five members of the ING protein family contain a conserved plant homeodomain (PHD) finger motif at the C-terminal end, commonly found in transcription factors that modulate chromatin structure.
ING proteins form transcriptional complexes that activate responsive genes involved in:
- Growth arrest
- DNA repair
- Gene transcription
- Apoptosis
- Senescence
The candidate tumor suppressor ING4 plays a role in brain tumor pathogenesis and regulates tumor growth and angiogenesis. Its expression is reduced in gliomas compared to normal brain tissue and correlates with tumor grade progression. ING4 interacts with the p65 (RelA) subunit of NF-κB and represses transcription of NF-κB responsive genes. Inactivating mutations and deletions of the ING4 locus have been observed in various human cancer cell lines and breast tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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