Thermo Fisher Scientific MCM10 Polyclonal Antibody
MCM10 단백질을 표적하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. 마우스 반응성, Rabbit IgG 호스트 기반으로 제작되었습니다. Western blot에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C에서 보관합니다.
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Applications
- Western Blot (WB): Tested dilution 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human MCM10 (aa 40–89) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690129 |
Product Specific Information
This target displays homology in the following species:
Cow: 92% | Dog: 86% | Guinea Pig: 92% | Human: 100% | Mouse: 100% | Rabbit: 92% | Rat: 100%
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) involved in the initiation of eukaryotic genome replication. The hexameric MCM complex is a key component of the pre-replication complex (pre-RC), contributing to replication fork formation and recruitment of other DNA replication-related proteins.
MCM10 interacts with MCM2, MCM6, and ORC2, and is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies in Xenopus suggest that chromatin binding occurs after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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