Thermo Fisher Scientific TNNI3 Monoclonal Antibody (OTI4E5), TrueMAB

Applications

• ELISA (ELISA): 1:100–1:1,000

Product Specifications

Target Information

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and movement.

Measurements of blood TnI and TnT levels are important diagnostic indicators of heart muscle damage and can differentiate between angina and myocardial infarction in patients with chest pain. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.