Thermo Fisher Scientific Enfortumab Recombinant Human Monoclonal Antibody
Enfortumab 인간 단일클론 항체로, Nectin-4를 표적으로 하는 재조합 항체입니다. ELISA 등 다양한 연구용 분석에 사용 가능하며, 고순도의 Protein A/G 정제 방식으로 제조되었습니다. 연구용으로만 사용되며, 냉동 보관이 필요합니다.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Human / IgG1, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Immunogen | Human PVRL4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911154 |
Product Specific Information
- Endotoxin level: < 0.01 EU/µg by LAL method
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Store at 2–8°C for one week.
- Store at -20 to -80°C for twelve months from the date of receipt.
Target Information
Enfortumab vedotin is an antibody-drug conjugate (ADC) used in the treatment of advanced, treatment-resistant urothelial cancers. It consists of a fully human monoclonal antibody targeting Nectin-4 linked via a protease-cleavable linker to the cytotoxic agent monomethyl auristatin E (MMAE).
This ADC mechanism is similar to brentuximab vedotin, which targets CD-30 instead of Nectin-4.
Enfortumab vedotin was developed through collaboration between Astellas Pharma and Seattle Genetics, and was first approved in the United States in December 2019 under the brand name Padcev™.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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