Thermo Fisher Scientific SESN1 Recombinant Rabbit Monoclonal Antibody (ARC2313)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

ELISA

• Tested Concentration: 1 µg/mL

Product Specifications

Product Specific Information

• Positive Samples: HepG2, PC-3
• Immunogen Sequence:
  KTQHYLLQMD GPLPLHYRHY IGIMAAARHQ CSYLVNLHVN DFLHVGGDPK WLNGLENAPQ KLQNLGELNK VLAHRPWLIT KEHIEGLLKA EEHSWSLAEL V

Target Information

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.