Thermo Fisher Scientific Adalimumab Chimeric Recombinant Rabbit Monoclonal Antibody (D2E7 (Adalimumab))
Adalimumab 특이적 재조합 토끼 단클론 항체로 TNF-α에 결합하여 염증 반응을 억제함. 인간 및 마우스 반응성, Protein A 정제, 액상 형태. IHC, ICC/IF, ELISA 등 다양한 연구용 응용에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | D2E7 (Adalimumab) |
| Immunogen | Generated by affinity maturation from the 2SD4 scFv, selected on human TNF alpha using guided phage-display technology, based on murine anti-hTNF alpha antibody Mab32. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074491 |
Product Specific Information
- Specificity: Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).
Target Information
Adalimumab (Humira) is a humanized monoclonal antibody approved by the U.S. FDA for treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, chronic psoriasis, hidradenitis suppurativa, and juvenile idiopathic arthritis.
It binds to TNF-alpha and blocks its interaction with TNF-alpha receptors, reducing the inflammatory response in autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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