Thermo Fisher Scientific BLNK Polyclonal Antibody
BLNK 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 적합. Human에 반응하며 Mouse, Rat, Bovine에 예측 반응. 항원 친화 크로마토그래피로 정제. PBS, 40% glycerol 용액 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 394–456 of BLNK (Uniprot ID: Q8WV28) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 40% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11155636 |
Product Specific Information
- Recommended positive controls: HeLa, HepG2, Molt-4, Raji
- Predicted reactivity: Mouse (100%), Rat (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
B cell linker protein (BLNK) is encoded by the Blnk gene located on chromosome 10 in humans. Also known as SLP-65 (Src homology 2 domain-containing leukocyte protein of 65 kDa), BLNK acts as an adaptor protein in the B cell receptor signaling cascade. Studies show that the absence of BLNK leads to improper B cell development. It undergoes tyrosine phosphorylation by Syk, a B cell receptor-activated kinase, providing a platform for interaction with signaling intermediaries such as Vav GEF and Grb2.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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