Thermo Fisher Scientific USP13 Polyclonal Antibody
Zebrafish에서 USP13 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 단백질 탈유비퀴틴화 연구에 적합. Protein A 및 항원 친화 크로마토그래피로 정제된 고순도 항체. 장기 보관 시 -20°C에서 안정적.
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Applications
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 387–420 amino acids from the central region of DANRE USP13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.86 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718059 |
Target Information
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2, and USP10, involved in processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). It is part of a regulatory loop controlling autophagy and p53/TP53 levels by stabilizing the PIK3C3/VPS34-containing complexes. Also regulates ERAD through deubiquitination of UBL4A, a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity by impairing SIAH2 autoubiquitination. Shows weak deubiquitinase activity in vitro, preferentially cleaving Lys-63-linked polyubiquitin chains. May cleave ISG15 in vitro. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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