Thermo Fisher Scientific Nur77 Monoclonal Antibody (12.14), PE, eBioscience
Mouse Nur77 단백질을 인식하는 PE 결합 단클론 항체로, 세포 내 염색 및 유세포분석(Flow Cytometry)에 적합합니다. 488–561 nm 레이저에서 여기되며, 578 nm에서 방출됩니다. 4°C 암소 보관, 동결 금지. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1 µg/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12.14 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1257210 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 647
- eFluor 450
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
Description:
This 12.14 monoclonal antibody reacts with mouse Nur77 (NR4A1, TR3, NGFI-B, NAK1), an inducible orphan nuclear receptor expressed in thymocytes and T cell lines. Nur77 promotes apoptosis and is involved in thymocyte negative selection. It also plays roles in steroid biosynthesis in Leydig cells, dopamine response, and interaction with FoxP3 in regulatory T cells.
Applications Reported:
For intracellular staining followed by flow cytometric analysis.
Applications Tested:
Tested by intracellular staining and flow cytometry of stimulated mouse thymocytes using the Foxp3/Transcription Factor Staining Buffer Set (Product #00-5523-00) and protocol.
Refer to BestProtocols®: Protocol B for intracellular (nuclear) proteins.
Recommended ≤1 µg/test in 100 µL final volume. Cell number: 10⁵–10⁸ cells/test. Optimize concentration for best results.
Excitation / Emission: 488–561 nm / 578 nm
Laser Compatibility: Blue, Green, Yellow-Green lasers
Filtration: 0.2 µm post-manufacturing filtered
Target Information
NR4A1 (Nur77):
A member of the steroid-thyroid hormone-retinoid receptor superfamily. Expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung, and prostate. Induced by stress stimuli and growth factors. Functions as a nuclear transcription factor mediating apoptotic signaling and hypothalamic-pituitary axis signaling. Translocation from nucleus to mitochondria induces apoptosis. Multiple transcript variants encode distinct isoforms; RXR is a known partner for NR4A1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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