ELK Biotechnology NFATc4 rabbit pAb
NFATc4 rabbit pAb는 인간 및 마우스 NFATC4 단백질을 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA 등 다양한 응용에 적합하며, 높은 특이성과 재현성을 제공합니다. 세포 내 NFAT 신호전달 연구 및 사이토카인 유전자 발현 분석에 활용됩니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology NFATc4 rabbit pAb
제품명
NFATc4 rabbit pAb
대체 명칭
NFATC4; NFAT3; Nuclear factor of activated T-cells, cytoplasmic 4; NF-ATc4; T-cell transcription factor NFAT3; NF-AT3
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NFAT3 (AA range: 642–691) |
| Species Reactivity | Human; Mouse |
| Host | Rabbit |
| Storage | −20°C (1 year) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 135 kD |
| GeneID (Human) | 4776 |
| Human Swiss-Prot No | Q14934 |
| Cellular Localization | Cytoplasm, cytosol, and nucleus. When hyperphosphorylated, localizes in the cytosol. Upon increased intracellular Ca(2+) levels, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (PubMed:11997522, PubMed:18347059). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (PubMed:18347059). |
배경 (Background)
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex consisting of a cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase calcineurin. The encoded protein plays a role in inducible expression of cytokine genes in T cells, particularly interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. (RefSeq, Jan 2014)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.