ELK Biotechnology Na+ CP-pan rabbit pAb
Na+ CP-pan rabbit pAb는 사람, 마우스, 랫트에서 나트륨 채널 단백질을 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며, 고특이성과 재현성을 제공합니다. 세포막 단백질 연구 및 신경세포 전위 전달 연구에 적합합니다.
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제품명
Na+ CP-pan rabbit pAb
제품 개요
Voltage-dependent sodium channel 단백질을 인식하는 폴리클로날 항체로, 세포막 단백질의 발현 및 기능 연구에 활용됩니다. 사람, 마우스, 랫트 시료에서 반응하며, 다양한 면역학적 응용에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Na+ CP-pan rabbit pAb |
| Alternative Names | SCN1A; NAC1; SCN1; Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1; SCN2A; NAC2; SCN2A1; SCN2A2; Sodium channel protein type II subunit alpha |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human Sodium Channel (AA range: 1466–1515) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 230 kDa |
| Gene ID (Human) | 6323, 6326, 6328, 6329, 6331, 6334, 6335, 6336, 11280 |
| Human Swiss-Prot No. | P35498, Q99250, Q9NY46, P35499, Q14524, Q9UQD0, Q15858, Q9Y5Y9, Q9UI33 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human, Mouse, Rat |
Background
Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium channel alpha subunit with four homologous domains, each containing six transmembrane regions. Allelic variants are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants, with four representative RefSeq records identified.
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