ELK Biotechnology MRTF-A rabbit pAb
MRTF-A 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 MKL1 유래 펩타이드로 면역화. 세포질 및 핵 내에서 위치 조절 연구에 적합. -20°C에서 1년 보관 가능.
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MRTF-A rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | MRTF-A rabbit pAb |
| Alternative Names | MKL1; KIAA1438; MAL; MKL/myocardin-like protein 1; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; Myocardin-related transcription factor A; MRTF-A |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MKL1 (AA range: 10-59) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 99 kDa |
| Gene ID (Human) | 57591 |
| Human Swiss-Prot No. | Q969V6 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasm and nucleus. Localization is regulated by actin dynamics: high nuclear G-actin levels reduce nuclear MRTF-A, while reduced nuclear G-actin promotes its nuclear accumulation. Binding of G-actin in the cytoplasm inhibits nuclear import by masking the NLS. MICAL2-mediated depolymerization of nuclear actin promotes nuclear retention and complex formation with SRF.
Background
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. It is predominantly nuclear and may transduce cytoskeletal signals to the nucleus. A specific translocation event involving this gene and RBM15 has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.
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