ELK Biotechnology MKP-1/2 rabbit pAb
인간 MKP-1/2 단백질을 인식하는 토끼 폴리클로날 항체로 WB, IHC, IF, ELISA에 적합합니다. 핵 내 위치 단백질 검출에 사용되며, 다양한 스트레스 반응 연구에 활용 가능합니다. 농도 1 mg/ml, -20°C에서 1년 보관.
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MKP-1/2 rabbit pAb
Supplier: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MKP-1/2 rabbit pAb |
| Alternative Names | DUSP1; CL100; MKP1; PTPN10; VH1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100; DUSP4 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MKP-1/2 (AA range: 261–310) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 41 kD |
| GeneID (Human) | 1843 / 1846 |
| Human Swiss-Prot No | P28562 / Q13115 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative or heat stress and growth factors. It encodes a protein similar to non-receptor-type protein-tyrosine phosphatase family members and shows sequence similarity to a Tyr/Ser-protein phosphatase encoded by the vaccinia virus H1 gene. The bacterially expressed DUSP1 protein exhibits intrinsic phosphatase activity, specifically inactivating mitogen-activated protein (MAP) kinase in vitro by dephosphorylating both phosphothreonine and phosphotyrosine residues. It also suppresses MAP kinase activation by oncogenic ras in Xenopus oocyte extracts. Thus, DUSP1 may play an important role in the cellular stress response and negative regulation of cell proliferation.
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