ELK Biotechnology MAD2 rabbit pAb
MAD2 단백질을 인식하는 토끼 폴리클로날 항체로, WB·IP·ELISA에 사용 가능. 인간 MAD2L1 유래 펩타이드로 면역생성. 핵, 중심체, 세포질 등 다양한 세포 위치에서 MAD2 검출에 적합. 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
MAD2 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
MAD2L1 단백질을 인식하는 토끼 폴리클로날 항체로, 세포 분열 시 방추체 조립 점검 단백질 검출에 사용됩니다.
스펙 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAD2L1; MAD2; Mitotic spindle assembly checkpoint protein MAD2A; HsMAD2; Mitotic arrest deficient 2-like protein 1; MAD2-like protein 1 |
| Applications | WB; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000, IP: 1/200–1/500, ELISA: 1/5000. Other applications not yet tested. |
| Immunogen | Synthesized peptide derived from human MAD2L1 (AA range: 91–140) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kD |
| GeneID (Human) | 4085 |
| Human Swiss-Prot No | Q13257 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치
Nucleus, chromosome centromere, kinetochore, cytoplasm, cytoskeleton, spindle pole.
Recruited by MAD1L1 to unattached kinetochores (Probable).
Recruited to the nuclear pore complex by TPR during interphase.
Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B, and CENPE.
Kinetochore association requires NEK2 and is repressed by UBD.
Sequestered to the cytoplasm upon interaction with isoform 3 of MAD1L1 (PubMed:19010891).
Background
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. (provided by RefSeq, Jul 2008)
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