ELK Biotechnology Liprin β1 rabbit pAb
Liprin β1 단백질에 특이적인 토끼 폴리클로날 항체로, WB 및 IHC에 사용 가능. 인간 및 생쥐 시료 반응성. 세포막 및 세포 접착 부위 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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Liprin β1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Liprin β1 rabbit pAb |
| Alternative Names | PPFIBP1; KIAA1230; Liprin-beta-1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF-interacting protein-binding protein 1; hSGT2 |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LIPB1. AA range: 300–349 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 115 kD |
| GeneID (Human) | 8496 |
| Human Swiss-Prot No | Q86W92 |
| Cellular Localization | Plasma membrane, cell-cell adherens junction, focal adhesion |
| Species Reactivity | Human; Mouse |
Background
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of the LAR family of transmembrane protein tyrosine phosphatases, which are important for axon guidance and mammary gland development. Liprins act as scaffolds for the recruitment and anchoring of LAR family phosphatases. This protein interacts with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiments demonstrated that the interaction inhibited phosphorylation of this protein by protein kinase C and CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. (RefSeq, Jul 2008)
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