ELK Biotechnology KDEL Receptor 2 rabbit pAb

KDEL Receptor 2 rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

Endoplasmic reticulum membrane; Multi-pass membrane protein.
Golgi apparatus membrane; Multi-pass membrane protein.
Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein.
Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L.
Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.

Background

KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2) Homo sapiens.
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae.
This process is mediated by a receptor that recognizes and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein.
Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product.