ELK Biotechnology KCNQ4 rabbit pAb
KCNQ4 단백질을 인식하는 토끼 폴리클로날 항체로, WB, ELISA, IHC에 사용 가능. 인간 KCNQ4 유래 펩타이드로 면역화. 청각 관련 칼륨 채널 연구에 적합하며, -20°C에서 1년 보관 가능.
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KCNQ4 rabbit pAb
제품 개요
KCNQ4 단백질을 인식하는 토끼 폴리클로날 항체입니다. 인간 KCNQ4 유래 합성 펩타이드(AA 644-693)를 면역원으로 사용하였으며, 신경흥분성과 청각 세포 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | KCNQ4 rabbit pAb |
| Alternative Names | KCNQ4; Potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–1:20000 |
| Immunogen | Synthesized peptide derived from human KCNQ4 (AA range: 644–693) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kDa |
| Gene ID (Human) | 9132 |
| Human Swiss-Prot No. | P56696 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Basal cell membrane; Multi-pass membrane protein. Situated at the basal membrane of cochlear outer hair cells. |
Background
The protein encoded by this gene forms a potassium channel that plays a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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