ELK Biotechnology JNK2 rabbit pAb
JNK2 rabbit pAb는 MAPK9 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능합니다. 세포 내 JNK2 신호전달 연구에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
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제품명
JNK2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAPK9; JNK2; PRKM9; SAPK1A; Mitogen-activated protein kinase 9; MAP kinase 9; MAPK 9; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAPK9 (AA range: 246–295) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| Gene ID (Human) | 5601 |
| Human Swiss-Prot No. | P45984 |
| Cellular Localization | Cytoplasm, Nucleus. Colocalizes with POU5F1 in the nucleus. |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase targets specific transcription factors, mediating immediate-early gene expression in response to various cell stimuli. It is closely related to MAPK8, both involved in UV radiation-induced apoptosis associated with the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. The kinase blocks the ubiquitination of tumor suppressor p53, increasing its stability in nonstressed cells. Studies of the mouse counterpart suggest a key role in T-cell differentiation.
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