ELK Biotechnology JIK rabbit pAb
TAOK3 단백질을 인식하는 JIK rabbit polyclonal antibody로, WB, ELISA, IHC에 적합합니다. 인간, 마우스, 랫트에서 반응하며 세포질 및 세포막에 위치한 단백질 검출에 유용합니다. 고순도 IgG 형식으로 -20°C에서 장기 보관 가능합니다.
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제품명
JIK rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TAOK3; DPK; JIK; KDS; MAP3K18; Serine/threonine-protein kinase TAO3; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from human TAOK3 (AA range: 531–580) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 110 kDa |
| Gene ID (Human) | 51347 |
| Human Swiss-Prot No. | Q9H2K8 |
| Cellular Localization | Cytoplasm; Cell membrane; Peripheral membrane protein; Also localized to the peripheral cell membrane |
| Species Reactivity | Human; Mouse; Rat |
Background
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Function: Inhibits the basal activity of Jun kinase; negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.
PTM: Autophosphorylated; phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity: Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily; contains one protein kinase domain.
Subcellular location: Also localized to the peripheral cell membrane.
Subunit: Self-associates.
Tissue specificity: Ubiquitously expressed at low levels, highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart, and liver.
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