ELK Biotechnology IL-5 rabbit pAb
IL-5 rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에 반응. WB, IHC, IF, ELISA에 사용 가능. 인간 IL-5 합성 펩타이드(AA 43-92)에 대해 제작. -20°C에서 1년 보관 가능. B세포 및 호산구 관련 연구에 적합.
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ELK Biotechnology IL-5 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | IL-5 rabbit pAb |
| Alternative Names | IL5; Interleukin-5; IL-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IL-5 (AA range: 43–92) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 30 kD |
| GeneID (Human) | 3567 |
| Human Swiss-Prot No | P05113 |
| Cellular localization | Secreted |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment, and survival. Increased production of this cytokine may be related to the pathogenesis of eosinophil-dependent inflammatory diseases.
This cytokine functions by binding to its receptor, which is a heterodimer whose beta subunit is shared with the receptors for interleukin 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF).
This gene is located on chromosome 5 within a cytokine gene cluster that includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2. IL5, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
[provided by RefSeq, Jul 2013]
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