ELK Biotechnology HLA-DOβ rabbit pAb
HLA-DOβ 단백질을 인식하는 토끼 폴리클로날 항체로, Western Blot 및 ELISA에 적합합니다. 인간 시료에 반응하며, 세포 내 엔도솜 및 리소좀 막 단백질 분석에 유용합니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology HLA-DOβ rabbit pAb
제품명
HLA-DOβ rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HLA-DOB (AA range: 1-50) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 30 kDa |
| Gene ID (Human) | 3112 |
| Human Swiss-Prot No. | P13765 |
| Species Reactivity | Human |
| Cellular Localization | Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER. |
Background
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26–28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain, and exon 5 encodes the cytoplasmic tail.
[provided by RefSeq, Jul 2008]
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.