Thermo Fisher Scientific GCN5 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GCN5 (KAT2A). Recognizes recombinant protein corresponding to amino acids 243–289. Supplied unconjugated in liquid form at 0.2 mg/mL. Suitable for research use in histone acetyltransferase and transcription st...
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KAT2A (amino acids 243–289) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791088 |
Product Specific Information
Immunogen sequence:
FSHLAPRERQ TMFELSKMFL LCLNYWKLET PAQFRQRSQA EDVATYK
Target Information
SAGA (Spt-Ada-Gcn5 histone acetyltransferase complex) is a histone acetylase complex with Gcn5p as the catalytic subunit. It functions in transcription regulation, overlapping with the fundamental transcription factor TFIID, which has Taf1p as its catalytic subunit.
SAGA and TFIID have distinct roles in transcription of housekeeping and stress-responsive genes. The SAGA complex consists of Ada proteins (5 types), TBP-related proteins (4 types), TAF proteins (5 types also found in TFIID), and other protein groups (>6 types).
Its molecular functions include histone modification, recruitment of transcription regulators via DNA interaction, and control of transcription initiation by TBP.
Gcn5p, showing histone acetylase activity, is one of the Ada proteins and in budding yeast consists of 439 amino acids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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