Thermo Fisher Scientific LAMB2 Polyclonal Antibody
Thermo Fisher Scientific의 LAMB2 Polyclonal Antibody는 인간 Laminin beta-2 단백질을 인식하는 고품질 항체로, Western blot과 ELISA에 적합합니다. Rabbit IgG 기반의 비결합형 액상 형태로, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1579–1798 of human LAMB2 (NP_002283.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.79 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855310 |
Product Specific Information
Immunogen sequence:
DVRRAEQLLQ DARRARSWAE DEKQKAETVQ AALEEAQRAQ GIAQGAIRGA VADTRDTEQT LYQVQERMAG AERALSSAGE RARQLDALLE ALKLKRAGNS LAASTAEETA GSAQGRAQEA EQLLRGPLGD QYQTVKALAE RKAQGVLAAQ ARAEQLRDEA RDLLQAAQDK LQRLQELEGT YEENERALES KAAQLDGLEA RMRSVLQAIN LQVQIYNTCQ
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane.
Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
- A-type lamins include lamin A, lamin C, and lamin Adel 10 (from the same gene by alternative splicing).
- B-type lamins include lamin B1 and lamin B2 (from distinct genes).
Mutations in A-type lamins are associated with rare dominant genetic disorders such as:
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy with conduction-system disease
- Dunnigan-type familial partial lipodystrophy
A-type lamins are expressed during cell differentiation and interact specifically with chromatin, suggesting a role in regulating differential gene expression.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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