Thermo Fisher Scientific LAMB2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
DVRRAEQLLQ DARRARSWAE DEKQKAETVQ AALEEAQRAQ GIAQGAIRGA VADTRDTEQT LYQVQERMAG AERALSSAGE RARQLDALLE ALKLKRAGNS LAASTAEETA GSAQGRAQEA EQLLRGPLGD QYQTVKALAE RKAQGVLAAQ ARAEQLRDEA RDLLQAAQDK LQRLQELEGT YEENERALES KAAQLDGLEA RMRSVLQAIN LQVQIYNTCQ

Target Information

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane.
Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.

• A-type lamins include lamin A, lamin C, and lamin Adel 10 (from the same gene by alternative splicing).
• B-type lamins include lamin B1 and lamin B2 (from distinct genes).

Mutations in A-type lamins are associated with rare dominant genetic disorders such as:

• Emery-Dreifuss muscular dystrophy
• Dilated cardiomyopathy with conduction-system disease
• Dunnigan-type familial partial lipodystrophy

A-type lamins are expressed during cell differentiation and interact specifically with chromatin, suggesting a role in regulating differential gene expression.

⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.