Thermo Fisher Scientific ABCA1 Polyclonal Antibody
Thermo Fisher Scientific의 ABCA1 Polyclonal Antibody는 마우스 ABCA1 단백질을 특이적으로 인식하는 토끼 유래 IgG 항체입니다. Western blot에 최적화되어 있으며, 친화 크로마토그래피로 정제되었습니다. Tangier 병 연구 등 지질 수송 관련 연구에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region of mouse ABCA1 (amino acids 1271–1320, UniProt ID: P41233-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688866 |
Product Specific Information
This target displays sequence homology across species as follows:
Cow: 93%; Dog: 86%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 86%
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD), an autosomal recessive disorder characterized by absence of plasma HDL, cholesterol ester accumulation in the reticuloendothelial system, and altered lipid trafficking.
ABCA1 mediates the apoA-I–dependent export of cholesterol and phospholipids from cells. It is localized to the plasma membrane and Golgi complex, and its expression is regulated by cholesterol flux. The balance of cholesterol transfer between HDL and macrophages involves competition between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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