Thermo Fisher Scientific IFIT5 Polyclonal Antibody
Rabbit polyclonal antibody against human IFIT5 for WB and ICC/IF applications. Recognizes interferon-induced RNA-binding protein involved in antiviral defense. Validated for research use only. Supplied as liquid, 0.4 mg/mL in PBS with 40% glycerol.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human IFIT5. Recombinant protein control fragment (Product #RP-105225) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663237 |
Product Specific Information
Immunogen sequence:
THNRPKGKDKL KVDELISSAI FHFKAAMERD SMFAFAYTDL ANMYAEGGQY SNAEDIFRKA LRLENITDDH KHQIHYH
Highest antigen sequence identity to the following orthologs:
- Mouse: 37%
- Rat: 39%
Target Information
Interferon-induced RNA-binding protein involved in the human innate immune response. Plays a key role in antiviral defense through broad RNA structure recognition. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically recognizes single-stranded RNA with a 5′-triphosphate group (PPP-RNA), serving as a sensor of viral RNAs. Distinguishes self from non-self mRNAs by detecting the absence of 2′-O-methylation on viral RNAs. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also binds AT-rich dsDNA (PubMed:23774268) and positively regulates IKK-NFKB signaling by recruiting IKK to MAP3K7 (PubMed:26334375). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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