Thermo Fisher Scientific APP Monoclonal Antibody (OTI7B8), TrueMAB
인간 APP 단백질을 인식하는 Mouse IgG1 단클론 항체로 WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. TrueMAB 포맷으로 고순도 Affinity chromatography 정제. PBS/BSA/glycerol 버퍼에 보관하며 -20°C에서 안정적 저장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B8 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1. APP plays a crucial role in neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein expressed in several isoforms due to alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques, a hallmark of Alzheimer’s disease. Abnormal APP processing is also implicated in Down’s syndrome, familial early-onset Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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