Thermo Fisher Scientific MTHFD1 Polyclonal Antibody
Thermo Fisher Scientific의 MTHFD1 Polyclonal Antibody는 인간 MTHFD1 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot과 IHC에 적합하며, 합성 펩타이드 면역원으로 제작되었습니다. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human MTHFD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2609492 |
Product Specific Information
Peptide sequence:
CMAKTHLSLS HNPEQKGVPT GFILPIRDIR ASVGAGFLYP LVGTMSTMPG
Sequence homology:
Cow: 93%
Dog: 100%
Guinea Pig: 86%
Horse: 100%
Human: 100%
Mouse: 100%
Pig: 100%
Rabbit: 100%
Rat: 100%
Yeast: 79%
Zebrafish: 79%
Target Information
This gene encodes a protein that possesses three distinct enzymatic activities:
- 5,10-methylenetetrahydrofolate dehydrogenase
- 5,10-methenyltetrahydrofolate cyclohydrolase
- 10-formyltetrahydrofolate synthetase
Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses.
The trifunctional enzymatic activities are conferred by two major domains:
- An aminoterminal portion containing the dehydrogenase and cyclohydrolase activities
- A larger synthetase domain
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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