Thermo Fisher Scientific Phospho-STAT1 (Ser727) Recombinant Rabbit Monoclonal Antibody (23GB4190)
Phospho-STAT1 (Ser727) 단백질을 검출하기 위한 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot, ICC/IF, Flow cytometry에 최적화. 인간, 생쥐, 랫드 반응성. 고순도 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific Phospho-STAT1 (Ser727) Recombinant Rabbit Monoclonal Antibody (Clone 23GB4190)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB4190 |
| Immunogen | A synthesized peptide derived from human Phospho-STAT1 (Ser727) (720–734AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
STAT1 (Signal Transducers and Activators of Transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism. It mediates cell viability in response to various stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2 and is activated to regulate gene expression in response to extracellular signaling polypeptides, including cytokines, interferons, and growth factors.
After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of multiple genes. Among the seven STAT types (STAT1, STAT3, STAT5a, STAT5b, etc.), STAT1 has a broad activation profile. It is activated by ligands such as IFN family (IFN-Alpha, IFN-Beta, IFN-Gamma, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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