Thermo Fisher Scientific PAX5 Monoclonal Antibody (52588)
Thermo Fisher Scientific의 PAX5 Monoclonal Antibody (Clone 52588)는 인간 PAX5 단백질을 인식하는 고특이성 항체입니다. Western blot 및 Flow cytometry에 적합하며, B세포 분화 관련 연구에 활용됩니다. 단백질 G 정제, 액상 형태로 제공되며 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 3 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 52588 |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 1–100 of Human PAX5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11000209 |
Product Specific Information
- For Western Blot, this antibody shows non-specific bands at 50 kDa.
- Predicted to react with mouse based on sequence homology.
Target Information
PAX5 is a member of the paired box (PAX) family of transcription factors. These proteins are crucial regulators in early development, and alterations in their expression are associated with neoplastic transformation.
PAX5 acts as a B-cell lineage specific activator protein (BSAP), expressed at early but not late stages of B-cell differentiation. Its expression is also detected in developing CNS and testis, suggesting roles in neural development and spermatogenesis.
Mutations in the PAX5 gene can lead to leukemia, including acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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