Thermo Fisher Scientific RED Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500
• Publications: -

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL
• Publications: -

Product Specifications

Product Specific Information

Immunogen sequence:
DMAVDSDEEV DYSKMDQGNK KGPLGRWDFD TQEEYSEYMN NKEALPKAAF QYGIKMSEGR KTRRFKETND KAELDRQWKK ISAIIEKRKK MEADGVEVKR PK

Target Information

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is expressed in a significantly higher proportion of melanomas than Spitz nevi, and in metastatic melanomas significantly more than in thin melanomas.
IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in regulating the biological behavior of this tumor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.