Thermo Fisher Scientific MLH1 Monoclonal Antibody (OTI4H6), TrueMAB
MLH1 단백질을 표적하는 Mouse IgG1 단일클론 항체로 Western blot 및 IHC(Paraffin) 분석에 적합. 인간 MLH1(aa 299-527) 재조합 단백질을 면역원으로 사용. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적인 PBS/BSA/glycerol 버퍼에 저장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 299–527 of human MLH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MLH1 is a DNA mismatch repair protein essential for maintaining genetic integrity. Defects in mismatch repair pathways can lead to microsatellite instability (MSI) and have been associated with human carcinogenesis. Mutations in mismatch repair genes, including MLH1, are linked to hereditary nonpolyposis colon cancer (HNPC). MSH2 participates in mismatch nucleotide recognition and forms a heterodimer with MLH1 and PMSH to facilitate subsequent repair steps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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