Thermo Fisher Scientific ATP2C1 Monoclonal Antibody (2G1)
ATP2C1 단백질을 인식하는 Thermo Fisher Scientific의 2G1 단클론 항체로, 인간 시료에 반응합니다. Western blot, ICC/IF, ELISA, IP 등 다양한 응용에 적합하며, PBS 버퍼에 보존된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G1 |
| Immunogen | ATP2C1 (AAH28139, 119–269 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
VQEYRSEKSL EELSKLVPPE CHCVREGKLE HTLARDLVPG DTVCLSVGDR VPADLRLFEA VDLSIDESSL TGETTPCSKV TAPQPAATNG DLASRSNIAF MGTLVRCGKA KGVVIGTGEN SEFGEVFKMM QAEEAPKTPL QKSMDLLGKQ L
Target Information
ATP2C1, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA1), belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes ATP hydrolysis coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in ATP2C1 cause Hailey-Hailey disease, an autosomal dominant disorder with persistent skin blisters and erosions.
Unlike the related ATP2C2 protein, ATP2C1 is ubiquitously expressed, showing lower turnover rate and higher affinity for Ca²⁺ activation of phosphorylation.
Recent evidence suggests ATP2C1 regulates insulin-like growth factor receptor (IGF1R) processing in tumor progression, particularly in basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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