Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), PerCP

Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), PerCP

Applications

• Flow Cytometry (Flow)

Tested Dilution: Assay-dependent
Publications: View 1 publication

Product Specifications

Additional Formats

• Alexa Fluor 488
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Cyanine7
• PE-Texas Red
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in T cell differentiation and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β), functioning as a co-receptor with TCR for MHC class I molecules. It is also found on NK cells, monocytes, and dendritic cells as CD8α homodimers. Engagement of MHC-I/peptide complexes recruits Lck kinase, inducing lymphokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are critical for pathogen and tumor clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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