Thermo Fisher Scientific YTHDF1 Polyclonal Antibody
YTHDF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA에 적합하며 Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, PBS/glycerol buffer 보존, -20°C 보관.
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Thermo Fisher Scientific YTHDF1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 280–390 of human YTHDF1 (NP_0602682) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.68 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855998 |
Product Specific Information
Immunogen sequence:
VPKAPVPQQA PSPQAAPQPQ QVAQPLPAQP PALAQPQYQS PQQPPQTRWV APRNRNAAFG QSGGAGSDSN SPGNVQPNSA PSVESHPVLE KLKAAHSYNP KEFEWNLKSG R
Target Information
YTHDF1 specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting mRNA translation efficiency. M6A modification affects mRNA splicing, processing, and stability.
YTHDF1 acts as a regulator of translation efficiency by facilitating ribosome loading and interacting with translation initiation factors eIF3. It plays roles in learning and memory formation, axon guidance, and antigen cross-presentation regulation in dendritic cells.
In tumorigenesis, negative regulation of antigen cross-presentation can limit anti-tumor responses.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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